SNX16

Entrez Summary: N/A
UniProt Summary: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extrinsic component of endosome membrane
negative regulation of ATPase activity
protein targeting to lysosome
early endosome to late endosome transport
vesicle-mediated transport between endosomal compartments
protein targeting to vacuole
protein localization to lysosome
establishment of protein localization to vacuole
endosome to lysosome transport
protein localization to vacuole
regulation of ATPase activity
phosphatidylinositol binding
lysosomal transport
late endosome membrane
late endosome
vacuolar transport
cytosolic transport
negative regulation of ion transport
early endosome membrane
lysosome
early endosome
protein targeting
regulation of membrane potential
establishment of protein localization to organelle
negative regulation of hydrolase activity
negative regulation of transport
intracellular membrane-bounded organelle
regulation of ion transport
protein localization to organelle
negative regulation of catalytic activity
intracellular protein transport
identical protein binding
negative regulation of molecular function
regulation of hydrolase activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization