EXOC8

Gene Information
  • Official Symbol: EXOC8
  • Official Name: exocyst complex component 8
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 149371
  • UniProt: Q8IYI6
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016].
  • UniProt Summary: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 2327
  • Expression level (log2 read counts): 5.51

Expression Distribution

  • Last modified: 2025/12/10 20:19
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