PFKP

Entrez Summary: This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
UniProt Summary: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R08 exp439	-3
Oligomycin-A 2μM R00 exp25	-2.25
Rotenone 0.07μM R08 exp431	-2.23
Rotenone 20μM R00 exp34	-2.05
Hypoxia 5%O2 R04 exp191	-1.97
LB-100 2μM R05 exp210	1.76
LY2090314 0.003μM R08 exp499	1.76
Campthothecin 0.001μM R06 exp270	1.78
All-trans-Retinoic-Acid 40μM R07 exp334	1.8
Hydroxyurea 100μM R07 exp329	1.8
Vemurafenib 6.6μM R02 exp89	1.8
Arsenate 40μM R06 exp264	1.86
Trichostatin-A 0.06μM R07 exp415	1.86
Vincristine 0.0005μM R04 exp190	1.87
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.88
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.88
Nicotine 3000μM R08 exp510	1.89
Thapsigargin 0.005μM R07 exp407	1.9
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.92
Dinaciclib 0.007μM R07 exp355	1.94
Quercetin 20μM R08 exp517	1.97
Olaparib 4μM R08 exp512	2.04
Aphidicolin 0.4μM R08 exp440	2.07
MLN-4924 0.2μM R00 exp21	2.09
Selumetinib 20μM R02 exp81	2.12
Vemurafenib 6.6μM R08 exp434	2.18
Clomiphene 4.4μM R02 exp68	2.23
Taxol 0.004μM R03 exp103	2.24
BS-181 20μM R08 exp461	2.3
Tubacin 1.6μM R07 exp416	2.32
MK-1775 0.32μM R02 exp75	2.35
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.41
Erlotinib 10μM R05 exp216	2.42
Docosahexaenoic-acid 50μM R07 exp356	2.48
Talazoparib 0.006μM R06 exp299	2.56
3-Bromopyruvate 7μM R04 exp175	2.61
Trimetrexate 0.03μM R08 exp535	2.85
UM0125461 0.74μM R02 exp84	3.11
Q15 2.7μM R02 exp79	3.39
2-Deoxy-D-glucose 800μM R05 exp214	7.65

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

6-phosphofructokinase complex
6-phosphofructokinase activity
fructose-6-phosphate binding
fructose 6-phosphate metabolic process
fructose 1,6-bisphosphate metabolic process
AMP binding
monosaccharide binding
NADH regeneration
glucose catabolic process to pyruvate
canonical glycolysis
glycolytic process through glucose-6-phosphate
glycolytic process through fructose-6-phosphate
glucose catabolic process
NADH metabolic process
glycolytic process
ATP generation from ADP
NAD metabolic process
ADP metabolic process
hexose catabolic process
nucleoside diphosphate phosphorylation
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
purine nucleoside diphosphate metabolic process
monosaccharide catabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
nucleoside diphosphate metabolic process
protein homotetramerization
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
glucose metabolic process
carbohydrate catabolic process
protein tetramerization
hexose metabolic process
monosaccharide metabolic process
ATP metabolic process
protein-containing complex binding
cadherin binding
purine ribonucleotide metabolic process
ribonucleotide metabolic process