TMEM208

Entrez Summary: N/A
UniProt Summary: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. {ECO:0000269|PubMed:23691174}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK-1775 0.32μM R02 exp75	-2.65
Bortezomib 0.005μM R00 exp6	-2.25
HMS-I2 1μM R06 exp286	-2.23
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.19
THZ531 0.225μM R08 exp444	-2.03
Golgicide-A 4μM R03 exp122	-1.95
MLN-4924 0.2μM R00 exp21	-1.9
Rifampicin 10μM R00 exp32	-1.86
2-Methoxyestradiol 0.2μM R01 exp40	-1.83
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.83
BI-2536 0.0042μM R03 exp95	-1.79
Rifampicin 1μM R00 exp31	-1.76
VER-155008 3.9μM R06 exp301	-1.76
Wortmannin 5μM R00 exp38	-1.76
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.74
UM131593 0.1μM R01 exp58	-1.7
TRAIL 50ng/ml R00 exp36	1.7
Staurosporine 0.02μM R08 exp524	1.83
Doxorubicin 0.02μM R08 exp478	1.95
PU-H71 1μM R08 exp515	1.99
SNS-032 15μM R08 exp443	2.02
Olaparib 4μM R08 exp512	2.29
MS023 2μM R03 exp134	2.56
Sulforaphane 9μM R08 exp525	2.62
Hippuristanol 0.12μM R08 exp488	2.63
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.74
Artemisinin 50μM R08 exp450	2.91
Tubacin 1.6μM R07 exp416	3.36
UM0125461 0.74μM R02 exp84	3.66
Arsenate 40μM R06 exp264	5.64

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vacuolar protein processing
vacuole
protein processing
protein maturation
process utilizing autophagic mechanism
autophagy
endoplasmic reticulum membrane
proteolysis
cellular catabolic process
gene expression