SLC20A1

Entrez Summary: The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011].
UniProt Summary: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:7966619, ECO:0000269|PubMed:8041748}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.02
BI-6727 0.0125μM R03 exp97	-1.9
Wortmannin 0.5μM R00 exp37	-1.76
TRAIL 5ng/ml R00 exp35	1.71
Rucaparib 6.5μM R08 exp520	1.72
Curcumin 6.5μM R06 exp277	1.73
Pterostilbene 16μM R02 exp78	1.74
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.76
Docosahexaenoic-acid 50μM R07 exp356	1.78
Rotenone 20μM R00 exp34	1.78
Rapamycin 10μM R00 exp30	1.8
MS023 7μM R03 exp135	1.81
Nutlin-3A 1.6μM R06 exp294	1.81
Actinomycin-D 0.001μM R00 exp3	1.84
SNS-032 15μM R08 exp443	1.85
LLY-283 2.6μM R06 exp290	1.87
Tubacin 1.6μM R07 exp416	1.89
Rotenone 2μM R00 exp33	1.95
Hippuristanol 0.12μM R08 exp488	1.98
Latrunculin-B 10μM R07 exp374	2
Aminopterin 0.005μM R07 exp335	2.05
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.08
AICAR 240μM R05 exp211	2.36
THZ1 0.06μM R08 exp531	2.44
MS023 2μM R03 exp134	2.56
Q15 2.7μM R02 exp79	2.69
Olaparib 4μM R08 exp512	3.5
Arsenate 40μM R06 exp264	8.34

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

high-affinity inorganic phosphate:sodium symporter activity
sodium:inorganic phosphate symporter activity
inorganic phosphate transmembrane transporter activity
sodium:phosphate symporter activity
phosphate ion transmembrane transport
phosphate ion transport
sodium ion transmembrane transport
biomineralization
biomineral tissue development
inorganic anion transmembrane transport
sodium ion transport
inorganic anion transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
signaling receptor activity
regulation of I-kappaB kinase/NF-kappaB signaling
anion transmembrane transport
monovalent inorganic cation transport
inorganic cation transmembrane transport
anion transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
positive regulation of intracellular signal transduction
transmembrane transport
ion transport
integral component of plasma membrane
positive regulation of signal transduction
tissue development
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
membrane