NFRKB

Entrez Summary: N/A
UniProt Summary: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 5μM R06 exp287	-2.83
Olaparib 4μM R08 exp512	-2.73
MK-1775 0.32μM R02 exp75	-2.57
HMS-I2 10μM R06 exp288	-2.45
Diepoxybutane 3μM R07 exp354	-2.39
LB-100 4.1μM R02 exp72	-2.07
LLY-283 2.6μM R06 exp290	-1.94
Resveratrol 16μM R03 exp147	-1.79
Trametinib 10μM R02 exp83	-1.77
Doxorubicin 0.02μM R08 exp478	-1.76
5-Fluorouracil 20μM R00 exp2	-1.75
Mubritinib 0.2μM R02 exp65	1.75
Q15 2.7μM R02 exp79	1.91
MLN-4924 0.2μM R00 exp21	2.18
Dimethyloxaloylglycine 100μM R05 exp229	2.33
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.44
Fluvastatin 2.2μM R06 exp282	2.47
I-BRD9 4μM R07 exp365	2.5
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.53
Amiloride 100μM R08 exp447	2.62
ML-792 0.2μM R08 exp505	2.75
LY2090314 0.003μM R08 exp500 no dilution day6	3.85
LY2090314 0.003μM R08 exp499	4.08
UM0125461 0.74μM R02 exp84	4.1
Tubacin 1.6μM R07 exp416	5.71

Global Fraction of Cell Lines Where Essential: 38/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	0/25
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	3/20
lung	3/75
lymphocyte	1/14
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	1/1
skin	5/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Ino80 complex
protease binding
DNA recombination
protein deubiquitination
protein modification by small protein removal
transcription by RNA polymerase II
inflammatory response
DNA repair
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA metabolic process
cellular response to DNA damage stimulus
protein modification by small protein conjugation or removal
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
proteolysis
organic cyclic compound biosynthetic process
defense response
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression