NFRKB [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NFRKB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFRKB
  * **<color #00a2e8>Official Name</color>**: nuclear factor related to kappaB binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4798|4798]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P4R8|Q6P4R8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFRKB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFRKB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164013|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ino80 complex|
|protease binding|
|DNA recombination|
|protein deubiquitination|
|protein modification by small protein removal|
|transcription by RNA polymerase II|
|inflammatory response|
|DNA repair|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|proteolysis|
|organic cyclic compound biosynthetic process|
|defense response|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.83|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.73|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.57|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.45|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.39|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.07|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.94|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.79|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.77|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.76|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.75|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.75|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.91|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.18|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.33|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.44|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.47|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.5|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.53|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.62|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.75|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|3.85|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|4.08|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|4.1|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|5.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:uchl5|UCHL5]]|0.784|
|[[:human genes:t:tfpt|TFPT]]|0.614|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.576|
|[[:human genes:i:ino80e|INO80E]]|0.559|
|[[:human genes:p:pih1d1|PIH1D1]]|0.538|
|[[:human genes:a:actr5|ACTR5]]|0.513|
|[[:human genes:i:ino80|INO80]]|0.49|
|[[:human genes:i:ino80c|INO80C]]|0.488|
|[[:human genes:i:ino80b|INO80B]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|3/28|
|bone|0/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|3/20|
|lung|3/75|
|lymphocyte|1/14|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4767
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFRKB Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>