PGP [The Human Chemical-Genetic Interaction Map Project]

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======= PGP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGP
  * **<color #00a2e8>Official Name</color>**: phosphoglycolate phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283871|283871]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NDG6|A6NDG6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). {ECO:0000250|UniProtKB:Q8CHP8, ECO:0000269|PubMed:26755581}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycerol-1-phosphatase activity|
|glycerol-3-phosphatase activity|
|phosphoglycolate phosphatase activity|
|glycerol biosynthetic process|
|nucleotide phosphatase activity, acting on free nucleotides|
|alditol biosynthetic process|
|negative regulation of gluconeogenesis|
|glycerol metabolic process|
|alditol metabolic process|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of gluconeogenesis|
|phosphatase activity|
|negative regulation of carbohydrate metabolic process|
|polyol biosynthetic process|
|cellular carbohydrate biosynthetic process|
|negative regulation of small molecule metabolic process|
|regulation of carbohydrate biosynthetic process|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|polyol metabolic process|
|alcohol biosynthetic process|
|regulation of glucose metabolic process|
|carbohydrate biosynthetic process|
|regulation of cellular carbohydrate metabolic process|
|cellular carbohydrate metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of carbohydrate metabolic process|
|protein dephosphorylation|
|magnesium ion binding|
|glycerophospholipid metabolic process|
|dephosphorylation|
|alcohol metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of small molecule metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.7|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.66|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.16|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.1|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.95|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.91|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.89|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.7|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.71|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.73|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.74|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.77|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.79|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.83|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.86|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.91|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.91|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.91|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.92|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.96|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.04|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.13|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.2|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.52|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.58|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.61|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.79|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.95|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.02|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|3.25|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.81|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|4.3|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|5.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gpi|GPI]]|0.578|
|[[:human genes:p:pgls|PGLS]]|0.569|
|[[:human genes:h:hk2|HK2]]|0.553|
|[[:human genes:p:pfkp|PFKP]]|0.512|
|[[:human genes:r:rpe|RPE]]|0.493|
|[[:human genes:s:slc2a1|SLC2A1]]|0.491|
|[[:human genes:t:tkt|TKT]]|0.458|
|[[:human genes:g:gpd2|GPD2]]|0.438|
|[[:human genes:c:coq3|COQ3]]|0.436|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.43|
|[[:human genes:v:vdac1|VDAC1]]|0.429|
|[[:human genes:c:crls1|CRLS1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1558
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGP Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>