GPD2 [The Human Chemical-Genetic Interaction Map Project]

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======= GPD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPD2
  * **<color #00a2e8>Official Name</color>**: glycerol-3-phosphate dehydrogenase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2820|2820]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43304|P43304]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAO|
|FAD oxidored|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity|
|glycerophosphate shuttle|
|glycerol-3-phosphate dehydrogenase (quinone) activity|
|glycerol-3-phosphate dehydrogenase [NAD+] activity|
|glycerol-3-phosphate dehydrogenase complex|
|glycerol-3-phosphate catabolic process|
|NADH oxidation|
|glycerol catabolic process|
|alditol catabolic process|
|glycerol-3-phosphate metabolic process|
|alditol phosphate metabolic process|
|glycerol metabolic process|
|alditol metabolic process|
|polyol catabolic process|
|NADH metabolic process|
|cellular carbohydrate catabolic process|
|gluconeogenesis|
|NAD metabolic process|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|alcohol catabolic process|
|cellular ketone metabolic process|
|organic hydroxy compound catabolic process|
|primary alcohol metabolic process|
|multicellular organism growth|
|polyol metabolic process|
|respiratory electron transport chain|
|glucose metabolic process|
|carbohydrate catabolic process|
|carbohydrate biosynthetic process|
|organophosphate catabolic process|
|hexose metabolic process|
|cellular respiration|
|cellular carbohydrate metabolic process|
|electron transport chain|
|carbohydrate derivative catabolic process|
|monosaccharide metabolic process|
|energy derivation by oxidation of organic compounds|
|camera-type eye development|
|alcohol metabolic process|
|eye development|
|visual system development|
|sensory system development|
|developmental growth|
|growth|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|sensory organ development|
|small molecule biosynthetic process|
|calcium ion binding|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.04|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.88|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.71|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.77|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|3.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pgp|PGP]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11101
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPD2 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>