DIAPH3

Entrez Summary: This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.002μM R01 exp45	-1.96
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.72
BAY-598 4μM R05 exp220	1.73
INK128 0.2μM R02 exp70	2.08
Mubritinib 0.2μM R02 exp65	2.51

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rho GTPase binding
actin filament polymerization
actin polymerization or depolymerization
protein polymerization
actin filament organization
actin binding
cadherin binding
supramolecular fiber organization
actin cytoskeleton organization
actin filament-based process
cellular protein-containing complex assembly
cytoskeleton organization
protein-containing complex assembly
protein-containing complex subunit organization