TACR3

Entrez Summary: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008].
UniProt Summary: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 11μM R07 exp314	-2.05
Mubritinib 0.2μM R02 exp65	-2.01
Milciclib 2μM R08 exp502	1.77
Cannabidiol 20μM R08 exp466	1.99
Actinomycin-D 0.01μM R00 exp4	2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7TM GPCR Srsx
7tm 1

tachykinin receptor activity
positive regulation of uterine smooth muscle contraction
tachykinin receptor signaling pathway
hyperosmotic salinity response
regulation of uterine smooth muscle contraction
positive regulation of cilium-dependent cell motility
positive regulation of flagellated sperm motility
regulation of flagellated sperm motility
regulation of catecholamine metabolic process
regulation of dopamine metabolic process
sperm midpiece
regulation of cilium-dependent cell motility
response to salt stress
hyperosmotic response
positive regulation of heart rate
neuronal cell body membrane
regulation of feeding behavior
dendrite membrane
positive regulation of smooth muscle contraction
response to isoquinoline alkaloid
response to morphine
positive regulation of blood pressure
positive regulation of heart contraction
positive regulation of muscle contraction
response to cocaine
regulation of smooth muscle contraction
positive regulation of blood circulation
regulation of behavior
response to osmotic stress
positive regulation of reproductive process
response to anesthetic
regulation of cellular amine metabolic process
regulation of heart rate
response to alkaloid
response to estradiol
regulation of muscle contraction
regulation of reproductive process
regulation of blood pressure
response to ammonium ion
regulation of muscle system process