TACR3 [The Human Chemical-Genetic Interaction Map Project]

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======= TACR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TACR3
  * **<color #00a2e8>Official Name</color>**: tachykinin receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6870|6870]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29371|P29371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TACR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TACR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162332|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to a family of genes that function as receptors for tachykinins.  Receptor affinities are specified by variations in the 5'-end of the sequence.  The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions.  This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tachykinin receptor activity|
|positive regulation of uterine smooth muscle contraction|
|tachykinin receptor signaling pathway|
|hyperosmotic salinity response|
|regulation of uterine smooth muscle contraction|
|positive regulation of cilium-dependent cell motility|
|positive regulation of flagellated sperm motility|
|regulation of flagellated sperm motility|
|regulation of catecholamine metabolic process|
|regulation of dopamine metabolic process|
|sperm midpiece|
|regulation of cilium-dependent cell motility|
|response to salt stress|
|hyperosmotic response|
|positive regulation of heart rate|
|neuronal cell body membrane|
|regulation of feeding behavior|
|dendrite membrane|
|positive regulation of smooth muscle contraction|
|response to isoquinoline alkaloid|
|response to morphine|
|positive regulation of blood pressure|
|positive regulation of heart contraction|
|positive regulation of muscle contraction|
|response to cocaine|
|regulation of smooth muscle contraction|
|positive regulation of blood circulation|
|regulation of behavior|
|response to osmotic stress|
|positive regulation of reproductive process|
|response to anesthetic|
|regulation of cellular amine metabolic process|
|regulation of heart rate|
|response to alkaloid|
|response to estradiol|
|regulation of muscle contraction|
|regulation of reproductive process|
|regulation of blood pressure|
|response to ammonium ion|
|regulation of muscle system process|
|regulation of heart contraction|
|aging|
|regulation of blood circulation|
|response to xenobiotic stimulus|
|blood circulation|
|circulatory system process|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of system process|
|response to lipid|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|response to abiotic stimulus|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of multicellular organismal process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.05|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.01|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.77|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.99|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15451
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TACR3 Expression in NALM6 Cells: -4.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>