SLC7A1

Entrez Summary: N/A
UniProt Summary: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. {ECO:0000269|PubMed:10485994}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.005μM R03 exp125	-1.86
Isonicotinamide 500μM R03 exp129	-1.82
Phenformin 20μM R05 exp212	1.7
Chloramphenicol 20μM R00 exp13	1.73
Rapamycin 0.001μM R08 exp429	1.74
Torin1 0.08μM R02 exp82	1.75
UM0129480 7μM R02 exp85	1.75
GSK-J4 1-1.25μM to day4 R07 exp363	1.77
Thimerosal 0.85μM R08 exp529	1.83
Rotenone 0.07μM R08 exp431	1.84
UMK57 1μM R01 exp59	1.85
Docosahexaenoic-acid 50μM R07 exp356	1.87
MK-1775 0.32μM R02 exp75	1.92
Artemisinin 50μM R08 exp450	1.93
BI-D1870 3.15μM R02 exp66	1.98
LY2090314 0.003μM R08 exp500 no dilution day6	1.98
Mubritinib 0.2μM R01 exp48	2.03
Milciclib 2μM R08 exp502	2.06
Deferoxamine 11μM R07 exp350	2.07
Centrinone 0.5μM R07 exp343	2.08
RK-33 8μM R08 exp518	2.13
UM0125461 0.74μM R02 exp84	2.17
Pterostilbene 16μM R02 exp78	2.18
Dorsomorphin 5μM R07 exp357	2.22
Citral 75μM R06 exp275	2.24
BVD-523 15μM R02 exp67	2.26
UM131593 0.2μM R03 exp106	2.26
LLY-283 2.6μM R06 exp290	2.27
Q15 2.7μM R02 exp79	2.29
QNZ 0.01μM R05 exp241	2.29
CB-839 10μM R05 exp224	2.31
WYE-354 6μM R02 exp90	2.32
Bisphenol A 100μM R06 exp269	2.41
Ethanol 0.01 R05 exp234	2.42
ETC-159 50μM R08 exp480	2.44
Arsenate 40μM R06 exp264	2.45
Calcium Ionophore 0.4μM R07 exp342	2.46
UM0131023 0.05μM R05 exp248	2.5
LY2090314 0.003μM R08 exp499	2.53
ML-792 0.2μM R08 exp505	2.63
Amiloride 100μM R08 exp447	2.64
Fluvastatin 2.2μM R06 exp282	2.72
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.81
CB-5083 0.4μM R08 exp468	2.89
Citral 50μM R06 exp274	3.08
Mubritinib 0.2μM R02 exp65	3.41
MLN-4924 0.2μM R00 exp21	4.88

Global Fraction of Cell Lines Where Essential: 14/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	2/16
ovary	0/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

L-arginine import across plasma membrane
arginine transmembrane transporter activity
L-lysine transmembrane transporter activity
L-ornithine transmembrane transporter activity
L-arginine transmembrane transport
L-lysine transmembrane transport
L-lysine transport
arginine transmembrane transport
L-arginine transport
L-ornithine transmembrane transport
ornithine transport
arginine transport
basic amino acid transmembrane transport
basic amino acid transport
amino acid import across plasma membrane
amino acid import
amino acid transmembrane transporter activity
L-alpha-amino acid transmembrane transport
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
import across plasma membrane
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
drug transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
organic anion transport
anion transport
protein-containing complex
cation transmembrane transport
import into cell
cation transport
ion transmembrane transport
response to drug
transmembrane transport
ion transport
integral component of plasma membrane