BCAT1

Entrez Summary: This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010].
UniProt Summary: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mubritinib 0.2μM R02 exp65	-2.24
Dynasore 7μM R08 exp436	-1.76

leucine biosynthetic process
branched-chain amino acid biosynthetic process
valine biosynthetic process
L-isoleucine transaminase activity
L-valine transaminase activity
L-leucine transaminase activity
branched-chain-amino-acid transaminase activity
valine metabolic process
leucine metabolic process
branched-chain amino acid metabolic process
branched-chain amino acid catabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
cellular amino acid catabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
mitotic cell cycle phase transition
cell cycle phase transition
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
small molecule catabolic process
small molecule biosynthetic process
mitotic cell cycle process
mitotic cell cycle
carboxylic acid metabolic process
cell cycle process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
identical protein binding
mitochondrion
cell cycle
organonitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process