ARID4A

• Official Symbol: ARID4A
• Official Name: AT-rich interaction domain 4A
• Aliases and Previous Symbols: N/A
• Entrez ID: 5926
• UniProt: P29374
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008].
• UniProt Summary: Interacts with the viral protein-binding domain of the retinoblastoma protein.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 18156
• Expression level (log2 read counts): 5.64

Expression Distribution

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ARID4A Expression in NALM6 Cells: 5.64