WBP11

Entrez Summary: N/A
UniProt Summary: Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.7
Betulinic acid 10 to 15μM on day4 R05 exp222	1.76
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.93
Lead acetate 2000μM R08 exp497	1.95
Etoposide 0.1μM R05 exp198	1.97
Lapatinib 5μM R01 exp47	2.16
Cytochalasin-B 5μM R07 exp349	2.49
Latrunculin-B 10μM R07 exp374	3.72
Tozasertib 0.1μM R07 exp414	3.72

Global Fraction of Cell Lines Where Essential: 730/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	28/29
uterus	5/5

Expression Distribution

WW domain binding
mRNA cis splicing, via spliceosome
single-stranded DNA binding
rRNA processing
rRNA metabolic process
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
ribosome biogenesis
RNA splicing, via transesterification reactions
ncRNA processing
RNA splicing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
mRNA processing
intracellular membrane-bounded organelle
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression