SNUPN

Entrez Summary: N/A
UniProt Summary: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:9670026}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 322/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	11/28
blood	6/28
bone	13/26
breast	13/33
central nervous system	37/56
cervix	1/4
colorectal	7/17
esophagus	5/13
fibroblast	1/1
gastric	8/16
kidney	11/21
liver	8/20
lung	33/75
lymphocyte	3/16
ovary	16/26
pancreas	12/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	1/1
skin	15/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	9/22
urinary tract	17/29
uterus	1/5

Expression Distribution

snRNA import into nucleus
RNA import into nucleus
snRNA transport
RNA cap binding
nuclear import signal receptor activity
spliceosomal snRNP assembly
nuclear pore
protein import into nucleus
import into nucleus
protein import
protein localization to nucleus
RNA transport
nucleic acid transport
establishment of RNA localization
RNA localization
ribonucleoprotein complex assembly
nucleobase-containing compound transport
ribonucleoprotein complex subunit organization
nucleocytoplasmic transport
nuclear transport
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
establishment of protein localization to organelle
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
protein localization to organelle
cellular protein-containing complex assembly
RNA processing
intracellular protein transport
protein transport
intracellular transport
peptide transport
protein-containing complex assembly
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization