SNUPN [The Human Chemical-Genetic Interaction Map Project]

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======= SNUPN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNUPN
  * **<color #00a2e8>Official Name</color>**: snurportin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10073|10073]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95149|O95149]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNUPN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNUPN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607902|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:9670026}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snurportin1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNA import into nucleus|
|RNA import into nucleus|
|snRNA transport|
|RNA cap binding|
|nuclear import signal receptor activity|
|spliceosomal snRNP assembly|
|nuclear pore|
|protein import into nucleus|
|import into nucleus|
|protein import|
|protein localization to nucleus|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|establishment of protein localization to organelle|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|protein localization to organelle|
|cellular protein-containing complex assembly|
|RNA processing|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.43|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.88|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.91|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wbp11|WBP11]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 322/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|6/28|
|bone|13/26|
|breast|13/33|
|central nervous system|37/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|11/21|
|liver|8/20|
|lung|33/75|
|lymphocyte|3/16|
|ovary|16/26|
|pancreas|12/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|17/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1339
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNUPN Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>