WBP11 [The Human Chemical-Genetic Interaction Map Project]

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======= WBP11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WBP11
  * **<color #00a2e8>Official Name</color>**: WW domain binding protein 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51729|51729]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2W2|Q9Y2W2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WBP11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WBP11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618083|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Wbp11|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|WW domain binding|
|mRNA cis splicing, via spliceosome|
|single-stranded DNA binding|
|rRNA processing|
|rRNA metabolic process|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|ribosome biogenesis|
|RNA splicing, via transesterification reactions|
|ncRNA processing|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|intracellular membrane-bounded organelle|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.7|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.76|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.93|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.95|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.97|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.16|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.49|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.72|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|3.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pqbp1|PQBP1]]|0.49|
|[[:human genes:s:sf3a2|SF3A2]]|0.451|
|[[:human genes:p:ppih|PPIH]]|0.441|
|[[:human genes:s:snupn|SNUPN]]|0.435|
|[[:human genes:c:c9orf78|C9orf78]]|0.425|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.424|
|[[:human genes:c:casp2|CASP2]]|0.415|
|[[:human genes:c:c2cd3|C2CD3]]|0.415|
|[[:human genes:c:cradd|CRADD]]|0.414|
|[[:human genes:h:hnrnpu|HNRNPU]]|0.414|
|[[:human genes:c:cltc|CLTC]]|0.41|
|[[:human genes:a:arid4b|ARID4B]]|0.405|
|[[:human genes:n:nin|NIN]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 730/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1563
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WBP11 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>