CCNT1

Gene Information

Official Symbol: CCNT1
Official Name: cyclin T1
Aliases and Previous Symbols: N/A
Entrez ID: 904
UniProt: O60563
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-1.74
Vinorelbine 0.001μM R05 exp249	1.71
Trimetrexate 0.03μM R08 exp535	1.75
Vinblastine 0.002μM R01 exp60	1.75
Cisplatin 0.35μM R06 exp273	1.78
THZ1 0.06μM R08 exp531	1.79
CoCl2 18μM R07 exp346	1.87
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.91
Tubacin 1.6μM R07 exp416	1.92
Thapsigargin 0.005μM R07 exp407	2.06
Rifampicin 10μM R00 exp32	2.14
3-Bromopyruvate 7μM R04 exp175	2.55
UM131593 0.2μM R03 exp106	2.55
Aminopterin 0.005μM R07 exp335	2.66
UMK57 1μM R01 exp59	2.72
Methotrexate 0.01μM R08 exp501	2.9

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	2/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 583
Expression level (log2 read counts): 7.07

Expression Distribution

7SK snRNA binding
negative regulation of mRNA polyadenylation
cyclin/CDK positive transcription elongation factor complex
negative regulation of mRNA 3-end processing
cyclin-dependent protein serine/threonine kinase activator activity
RNA polymerase binding
positive regulation by host of viral transcription
regulation of mRNA polyadenylation
negative regulation of mRNA processing
regulation of mRNA 3-end processing
positive regulation of DNA-templated transcription, elongation
positive regulation of cyclin-dependent protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase regulator activity
positive regulation of cyclin-dependent protein kinase activity
positive regulation of viral transcription
regulation of DNA-templated transcription, elongation
regulation of viral transcription
snRNA transcription by RNA polymerase II
modification by host of symbiont morphology or physiology
snRNA transcription
transcription elongation from RNA polymerase II promoter
interaction with symbiont
negative regulation of mRNA metabolic process
DNA-templated transcription, elongation
ncRNA transcription
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
regulation of mRNA processing
modification of morphology or physiology of other organism
regulation of viral process
transcription regulatory region DNA binding
regulation of symbiosis, encompassing mutualism through parasitism
regulation of mRNA metabolic process
transcription factor binding
positive regulation of protein serine/threonine kinase activity
positive regulation of cell cycle
chromatin binding
protein kinase binding