CCNT1 [The Human Chemical-Genetic Interaction Map Project]

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======= CCNT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNT1
  * **<color #00a2e8>Official Name</color>**: cyclin T1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=904|904]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60563|O60563]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/143055|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|7SK snRNA binding|
|negative regulation of mRNA polyadenylation|
|cyclin/CDK positive transcription elongation factor complex|
|negative regulation of mRNA 3-end processing|
|cyclin-dependent protein serine/threonine kinase activator activity|
|RNA polymerase binding|
|positive regulation by host of viral transcription|
|regulation of mRNA polyadenylation|
|negative regulation of mRNA processing|
|regulation of mRNA 3-end processing|
|positive regulation of DNA-templated transcription, elongation|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|positive regulation of cyclin-dependent protein kinase activity|
|positive regulation of viral transcription|
|regulation of DNA-templated transcription, elongation|
|regulation of viral transcription|
|snRNA transcription by RNA polymerase II|
|modification by host of symbiont morphology or physiology|
|snRNA transcription|
|transcription elongation from RNA polymerase II promoter|
|interaction with symbiont|
|negative regulation of mRNA metabolic process|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of mRNA processing|
|modification of morphology or physiology of other organism|
|regulation of viral process|
|transcription regulatory region DNA binding|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of mRNA metabolic process|
|transcription factor binding|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|chromatin binding|
|protein kinase binding|
|transcription by RNA polymerase II|
|cell division|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|viral process|
|regulation of multi-organism process|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|nucleolus|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.74|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.71|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.75|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.75|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.78|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.79|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.87|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.91|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.92|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.06|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.14|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.55|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.55|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.66|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.72|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|2/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNT1 Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>