RXFP2

Entrez Summary: This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
UniProt Summary: Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R01 exp48	-2.59
Vemurafenib 6.6μM R02 exp89	-2.09
Cisplatin 0.35μM R06 exp273	-1.93
Hydroxyurea 100μM R07 exp329	-1.86
CCT251545 20μM R07 exp326	-1.84
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.84
TIC10 10μM R08 exp532	-1.82
FBS-Wisent 0.1 R07 exp426	-1.79
Vitamin-D3 40μM R08 exp536	-1.76
Lapatinib 5μM R01 exp47	-1.72
Tubacin 1.6μM R07 exp416	-1.72
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.77
QNZ 0.01μM R08 exp439	1.82
Lenalidomide 20μM R07 exp375	1.86
SGC0946 7μM R03 exp151	2.18
Taxol 0.004μM R03 exp103	2.19
Brefeldin A 0.02μM R00 exp8	2.23
Phenformin 20μM R05 exp212	2.25
Rifampicin 10μM R00 exp32	2.31
Artemisinin 50μM R08 exp450	2.46
Celastrol 0.12μM R05 exp225	2.6

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein-hormone receptor activity
oocyte maturation
positive regulation of cAMP-mediated signaling
oocyte development
activation of adenylate cyclase activity
G protein-coupled peptide receptor activity
peptide hormone binding
oocyte differentiation
regulation of cAMP-mediated signaling
oogenesis
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
adenylate cyclase-activating G protein-coupled receptor signaling pathway
female gamete generation
male gonad development
development of primary male sexual characteristics
anatomical structure maturation
cAMP-mediated signaling
male sex differentiation
cell maturation
hormone-mediated signaling pathway
cyclic-nucleotide-mediated signaling
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
gonad development
development of primary sexual characteristics
developmental maturation
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
germ cell development
sex differentiation
second-messenger-mediated signaling
cellular process involved in reproduction in multicellular organism
reproductive structure development
reproductive system development
cellular response to hormone stimulus
developmental process involved in reproduction
negative regulation of cell population proliferation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
negative regulation of apoptotic process