GRHL1

Gene Information

Official Symbol: GRHL1
Official Name: grainyhead like transcription factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 29841
UniProt: Q9NZI5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed (PubMed:12175488). {ECO:0000250|UniProtKB:Q921D9, ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:18288204}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12738
Expression level (log2 read counts): 3.61

Expression Distribution

Screen	Score
TRAIL 5ng/ml R00 exp35	1.7
Salubrinal 20μM R07 exp399	2.01
PT-1 25μM R07 exp392	2.15

desmosome organization
establishment of skin barrier
regulation of water loss via skin
regulation of keratinocyte differentiation
regulation of epidermal cell differentiation
multicellular organismal water homeostasis
chromatin DNA binding
water homeostasis
regulation of epidermis development
cell-cell junction organization
regulation of epithelial cell differentiation
cell junction organization
transcription regulatory region DNA binding
multicellular organismal homeostasis
skin development
regulation of lipid metabolic process
epidermis development
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of body fluid levels
RNA polymerase II proximal promoter sequence-specific DNA binding
DNA-binding transcription factor activity
intracellular membrane-bounded organelle
protein homodimerization activity
Golgi apparatus
chemical homeostasis
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
homeostatic process
positive regulation of RNA metabolic process
tissue development
regulation of cell differentiation
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process