TAX1BP3

Gene Information

Official Symbol: TAX1BP3
Official Name: Tax1 binding protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 30851
UniProt: O14907
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017].
UniProt Summary: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:16855024, ECO:0000269|PubMed:21139582}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Apcin 50 to 100μM on day4 R04 exp176	-1.94
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.8
MS023 7μM R03 exp135	1.93
PT-1 25μM R07 exp392	2.06

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18159
Expression level (log2 read counts): 3.74

Expression Distribution

negative regulation of protein localization to cell surface
regulation of protein localization to cell surface
Rho protein signal transduction
beta-catenin binding
activation of GTPase activity
negative regulation of cellular protein localization
fibrillar center
protein C-terminus binding
negative regulation of Wnt signaling pathway
actin cytoskeleton
Ras protein signal transduction
small GTPase mediated signal transduction
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
positive regulation of GTPase activity
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of GTPase activity
regulation of cellular protein localization
negative regulation of cell population proliferation
intracellular membrane-bounded organelle
positive regulation of hydrolase activity
regulation of cellular localization
regulation of protein localization
cell-cell signaling
negative regulation of signal transduction
regulation of hydrolase activity
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity
regulation of cell population proliferation
negative regulation of response to stimulus
intracellular signal transduction
positive regulation of molecular function