NHP2L1

Entrez Summary: Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cytochalasin-B 5μM R07 exp349	-2.58
CR131-b 0.005μM R08 exp474	-2.41
Vinblastine 0.015μM R05 exp208	-2.15
AICAR 240μM R05 exp211	-2.07
SB743921 0.001μM R05 exp244	-2.04
DABN racemic mixture R03 exp93	-2.03
Vemurafenib 6.6μM R08 exp434	-2.02
Olaparib 4μM R08 exp512	-1.98
Palbociclib 1μM R07 exp382	-1.91
BI-2536 0.02μM R03 exp96	-1.87
Tanespimycin 14μM R08 exp527	-1.73
Nifurtimox 1μM R03 exp141	1.7
GSK461364A 0.005μM R03 exp125	1.71
Adefovir 20μM R07 exp332	1.71
BI-2536 0.001μM R01 exp41	1.72
Temozolomide 200μM R04 exp189	1.73
Chlorpromazine 10μM R07 exp344	1.74
Daidzin 10μM R06 exp280	1.74
Metformin 100 to 150μM on day4 R04 exp170	1.74
Resminostat 0.5μM R07 exp393	1.76
DKK1 89ng/ml R08 exp477	1.77
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.78
Chloramphenicol 20μM R00 exp13	1.83
Rapamycin 1μM R00 exp29	1.85
L-74142 5μM R03 exp131	1.86
Cyclosporin-A 3μM R07 exp348	1.89
Cadmium 60μM R08 exp462	1.92
Trientine 500μM R08 exp534	1.94
CCCP 1μM R00 exp11	1.95
NMS-873 0.07μM R07 exp380	1.98
Ibrutinib 1μM R07 exp372	2.02
Doxycycline 10μM R00 exp18	2.06
Nifuroxazide 5μM R03 exp102	2.11
PT-1 25μM R07 exp392	2.12
NFN1 1μM R03 exp100	2.16
S-DABN 8μM R03 exp112	2.56
Citral 75μM R06 exp275	2.65
Wortmannin 0.5μM R00 exp37	2.75

Global Fraction of Cell Lines Where Essential: 726/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	26/28
bone	26/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	18/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

box C/D snoRNA binding
U4atac snRNP
dense fibrillar component
U4atac snRNA binding
U4 snRNA binding
U3 snoRNA binding
box C/D snoRNP complex
box C/D snoRNP assembly
small nucleolar ribonucleoprotein complex assembly
snoRNA binding
maturation of LSU-rRNA
U4/U6 x U5 tri-snRNP complex
small-subunit processome
U2-type precatalytic spliceosome
ribosomal large subunit biogenesis
ATPase binding
single fertilization
fertilization
rRNA processing
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
ribosome biogenesis
RNA splicing, via transesterification reactions
ncRNA processing
RNA splicing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
mRNA processing
protein-containing complex
mRNA metabolic process
sexual reproduction
cellular protein-containing complex assembly
nucleolus
RNA processing
multi-organism reproductive process
RNA binding
reproductive process