NHP2L1 [The Human Chemical-Genetic Interaction Map Project]

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======= NHP2L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNU13
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4809|4809]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55769|P55769]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NHP2L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NHP2L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601304|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L7Ae|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|box C/D snoRNA binding|
|U4atac snRNP|
|dense fibrillar component|
|U4atac snRNA binding|
|U4 snRNA binding|
|U3 snoRNA binding|
|box C/D snoRNP complex|
|box C/D snoRNP assembly|
|small nucleolar ribonucleoprotein complex assembly|
|snoRNA binding|
|maturation of LSU-rRNA|
|U4/U6 x U5 tri-snRNP complex|
|small-subunit processome|
|U2-type precatalytic spliceosome|
|ribosomal large subunit biogenesis|
|ATPase binding|
|single fertilization|
|fertilization|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|ribosome biogenesis|
|RNA splicing, via transesterification reactions|
|ncRNA processing|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|protein-containing complex|
|mRNA metabolic process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|multi-organism reproductive process|
|RNA binding|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.58|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.41|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.15|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.07|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.04|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.03|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.02|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.98|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.91|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.87|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.73|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.7|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.71|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.71|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.72|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.73|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.74|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.74|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.74|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.76|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.77|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.78|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.83|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.85|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.86|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.89|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.92|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.94|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.95|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.98|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.02|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.06|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.11|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.12|
|[[:results:exp100|NFN1 1μM R03 exp100]]|2.16|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.56|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.65|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.555|
|[[:human genes:p:pole|POLE]]|0.484|
|[[:human genes:c:cdca3|CDCA3]]|0.466|
|[[:human genes:n:nbpf16|NBPF16]]|0.419|
|[[:human genes:p:pola2|POLA2]]|0.416|
|[[:human genes:p:paf1|PAF1]]|0.409|
|[[:human genes:z:znf655|ZNF655]]|0.403|
|[[:human genes:p:psmb4|PSMB4]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|18/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NHP2L1 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>