SYNE2

Entrez Summary: The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hydroxyurea 15μM R06 exp289	1.74
Staurosporine 0.02μM R08 exp524	1.74
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.84
Ibrutinib 1μM R07 exp372	1.92
Ethambutol 25μM R08 exp481	2
LLY-284 2.6μM R06 exp291	2.12
Rifampicin 30μM R08 exp430	2.26

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nuclear migration along microfilament
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
nuclear lumen
modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
nuclear migration along microtubule
cell motility involved in cerebral cortex radial glia guided migration
actin filament-based transport
cytoskeletal anchoring at nuclear membrane
meiotic nuclear membrane microtubule tethering complex
centriole-centriole cohesion
filopodium membrane
telencephalon glial cell migration
cerebral cortex radial glia guided migration
lamellipodium membrane
nuclear migration
nuclear outer membrane
nucleus localization
cerebral cortex radially oriented cell migration
centrosome localization
microtubule organizing center localization
sarcoplasmic reticulum membrane
glial cell migration
aggresome
cerebral cortex cell migration
sarcoplasmic reticulum
intermediate filament cytoskeleton
telencephalon cell migration
forebrain cell migration
maintenance of protein location in cell
organelle transport along microtubule
regulation of cilium assembly
centrosome cycle
microtubule organizing center organization
maintenance of location in cell
maintenance of protein location
actin filament-based movement
cerebral cortex development
Z disc
transport along microtubule
maintenance of location