NUDT18

Gene Information

Official Symbol: NUDT18
Official Name: nudix hydrolase 18
Aliases and Previous Symbols: N/A
Entrez ID: 79873
UniProt: Q6ZVK8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012].
UniProt Summary: Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. {ECO:0000269|PubMed:22556419}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ethambutol 25μM R08 exp481	-1.92
Vemurafenib 6.6μM R02 exp89	1.79
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.82
5-Azacytidine 2μM R07 exp330	1.88
Senexin-A 25μM R07 exp400	1.97
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.08
Fas-L 44ng/ml R08 exp482	2.34

Essentiality in NALM6

Essentiality Rank: 10459
Expression level (log2 read counts): 1.47

Expression Distribution

GDP catabolic process
deoxyribonucleoside diphosphate catabolic process
8-hydroxy-dADP phosphatase activity
dADP catabolic process
8-oxo-GDP phosphatase activity
dGDP catabolic process
purine deoxyribonucleoside diphosphate catabolic process
8-oxo-dGDP phosphatase activity
dADP metabolic process
dGDP metabolic process
purine ribonucleoside diphosphate catabolic process
guanosine-containing compound catabolic process
purine nucleoside diphosphate catabolic process
purine deoxyribonucleoside diphosphate metabolic process
deoxyribonucleoside diphosphate metabolic process
purine deoxyribonucleotide catabolic process
ribonucleoside diphosphate catabolic process
nucleoside diphosphate catabolic process
purine ribonucleoside catabolic process
purine nucleoside catabolic process
GDP metabolic process
purine deoxyribonucleotide metabolic process
deoxyribonucleotide catabolic process
deoxyribose phosphate catabolic process
ribonucleoside catabolic process
2-deoxyribonucleotide metabolic process
purine ribonucleotide catabolic process
deoxyribose phosphate metabolic process
ribonucleotide catabolic process
deoxyribonucleotide metabolic process
nucleoside catabolic process
guanosine-containing compound metabolic process
glycosyl compound catabolic process
purine nucleotide catabolic process
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process
purine ribonucleoside metabolic process
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process