ZBTB10

Gene Information

Official Symbol: ZBTB10
Official Name: zinc finger and BTB domain containing 10
Aliases and Previous Symbols: N/A
Entrez ID: 65986
UniProt: Q96DT7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in transcriptional regulation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 5ng/ml R00 exp35	-4.23
Dimethyloxaloylglycine 100μM R05 exp229	-3.58
Hydroxyurea 100μM R07 exp329	-3.01
CB-5083 0.4μM R08 exp468	-2.87
Rapamycin 10μM R00 exp30	-2.82
GSK626616 14μM R08 exp485	-2.79
Wortmannin 5μM R00 exp38	-2.74
I-BRD9 4μM R07 exp365	-2.7
Diepoxybutane 3μM R07 exp354	-2.67
TRAIL 50ng/ml R00 exp36	-2.6
Tubacin 1.6μM R07 exp416	-2.59
All-trans-Retinoic-Acid 8μM R07 exp333	-2.53
Lead acetate 2000μM R08 exp498 no dilution day6	-2.34
Lead acetate 2000μM R08 exp497	-2.33
Bleomycin 5μM R08 exp459	-2.32
All-trans-Retinoic-Acid 40μM R07 exp334	-2.31
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.31
LY2090314 0.003μM R08 exp500 no dilution day6	-2.26
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.25
2-Methoxyestradiol 0.55μM R07 exp310	-2.22
LY2090314 0.003μM R08 exp499	-2.2
Clomiphene 4.4μM R02 exp68	-2.17
Dynasore 7μM R08 exp436	-2.14
3-Bromopyruvate 7μM R04 exp175	-2.12
Aphidicolin 0.4μM R08 exp440	-2.07
Pimelic-diphenylamide-106 5μM R00 exp28	-2.06
Tanespimycin 14μM R08 exp527	-2.04
Thimerosal 0.85μM R08 exp529	-2.03
Wortmannin 0.5μM R00 exp37	-1.97
Etoposide 10μM R00 exp20	-1.92
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.91
Hippuristanol 0.12μM R08 exp488	-1.89
Dynasore 10μM R04 exp180	-1.86
TNF-alpha 44ng/ml R08 exp533	-1.82
42°C R08 exp539	-1.79
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.79
Nutlin-3A 1.6μM R06 exp294	-1.76
Etoposide 1μM R00 exp19	-1.75
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.74
Vincristine 0.0005μM R04 exp190	-1.71
UM0129480 7μM R02 exp85	-1.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6805
Expression level (log2 read counts): 5.4

Expression Distribution