ZBTB10 [The Human Chemical-Genetic Interaction Map Project]

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======= ZBTB10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZBTB10
  * **<color #00a2e8>Official Name</color>**: zinc finger and BTB domain containing 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65986|65986]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DT7|Q96DT7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZBTB10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZBTB10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618576|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-4.23|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-3.58|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-3.01|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.87|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.82|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.79|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.74|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.7|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.67|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.6|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.59|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.53|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.34|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.33|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.32|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.31|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.31|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.26|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.25|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.22|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.2|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.17|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.14|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.12|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.07|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.06|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.04|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.03|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.97|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.92|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.91|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.89|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.86|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.82|
|[[:results:exp539|42°C R08 exp539]]|-1.79|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.79|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.76|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.75|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.74|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.71|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6805
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZBTB10 Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>