MPC2
Gene Information
- Official Symbol: MPC2
- Official Name: mitochondrial pyruvate carrier 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 25874
- UniProt: O95563
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mediates the uptake of pyruvate into mitochondria. {ECO:0000269|PubMed:22628558}.
Pfam Domains GO Terms
Pfam Domains
| UPF0041 |
GO Terms
| mitochondrial pyruvate transmembrane transport |
| pyruvate transport |
| pyruvate transmembrane transporter activity |
| pyruvate transmembrane transport |
| mitochondrial acetyl-CoA biosynthetic process from pyruvate |
| acetyl-CoA biosynthetic process from pyruvate |
| acetyl-CoA biosynthetic process |
| acetyl-CoA metabolic process |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| integral component of mitochondrial inner membrane |
| acyl-CoA biosynthetic process |
| thioester biosynthetic process |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| ribonucleoside bisphosphate biosynthetic process |
| nucleoside bisphosphate biosynthetic process |
| purine nucleoside bisphosphate biosynthetic process |
| pyruvate metabolic process |
| positive regulation of insulin secretion |
| mitochondrial transmembrane transport |
| thioester metabolic process |
| positive regulation of peptide hormone secretion |
| acyl-CoA metabolic process |
| carboxylic acid transmembrane transport |
| positive regulation of hormone secretion |
| organic acid transmembrane transport |
| nucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| ribonucleoside bisphosphate metabolic process |
| coenzyme biosynthetic process |
| monocarboxylic acid transport |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| regulation of insulin secretion |
| sulfur compound biosynthetic process |
| regulation of peptide hormone secretion |
| cofactor biosynthetic process |
| mitochondrial transport |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| anion transmembrane transport |
| positive regulation of peptide secretion |
| organic acid transport |
| carboxylic acid transport |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic anion transport |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of peptide secretion |
| amide biosynthetic process |
| monocarboxylic acid metabolic process |
| regulation of hormone levels |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| anion transport |
| carbohydrate derivative biosynthetic process |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| cellular amide metabolic process |
| regulation of secretion |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| regulation of cellular localization |
| ion transmembrane transport |
| positive regulation of transport |
| oxoacid metabolic process |
| organic acid metabolic process |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| mitochondrion |
| transmembrane transport |
| organic cyclic compound biosynthetic process |
| ion transport |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ531 0.11 to 0.125μM on day4 R07 exp410 | 1.71 |
| CB-839 10μM R05 exp224 | 1.74 |
| CoCl2 18μM R07 exp346 | 1.91 |
| Cycloheximide 0.2μM R00 exp15 | 2.17 |
| Wortmannin 5μM R00 exp38 | 2.63 |
| Nifuroxazide 5μM R03 exp102 | 5.15 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7703
- Expression level (log2 read counts): 4.77
Expression Distribution
MPC2 Expression in NALM6 Cells: 4.77
