MPC1

Entrez Summary: The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012].
UniProt Summary: Mediates the uptake of pyruvate into mitochondria. {ECO:0000269|PubMed:22628558}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial pyruvate transmembrane transport
pyruvate transport
pyruvate transmembrane transporter activity
pyruvate transmembrane transport
mitochondrial acetyl-CoA biosynthetic process from pyruvate
acetyl-CoA biosynthetic process from pyruvate
acetyl-CoA biosynthetic process
acetyl-CoA metabolic process
integral component of mitochondrial inner membrane
acyl-CoA biosynthetic process
thioester biosynthetic process
ribonucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
pyruvate metabolic process
mitochondrial transmembrane transport
thioester metabolic process
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
acyl-CoA metabolic process
carboxylic acid transmembrane transport
organic acid transmembrane transport
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
coenzyme biosynthetic process
monocarboxylic acid transport
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
cofactor biosynthetic process
mitochondrial transport
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
anion transmembrane transport
organic acid transport