CD74
Gene Information
- Official Symbol: CD74
- Official Name: CD74 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 972
- UniProt: P04233
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| MHCassoc trimer |
| MHC2-interact |
| Thyroglobulin 1 |
GO Terms
| MHC class II protein binding, via antigen binding groove |
| macrophage migration inhibitory factor signaling pathway |
| NOS2-CD74 complex |
| macrophage migration inhibitory factor binding |
| macrophage migration inhibitory factor receptor complex |
| positive regulation of macrophage migration inhibitory factor signaling pathway |
| regulation of macrophage migration inhibitory factor signaling pathway |
| regulation of mature B cell apoptotic process |
| negative regulation of mature B cell apoptotic process |
| positive regulation of prostaglandin biosynthetic process |
| MHC class II protein binding |
| positive regulation of dendritic cell antigen processing and presentation |
| CD4 receptor binding |
| positive regulation of unsaturated fatty acid biosynthetic process |
| positive regulation of antigen processing and presentation |
| regulation of prostaglandin biosynthetic process |
| positive regulation of macrophage cytokine production |
| positive regulation of chemokine (C-X-C motif) ligand 2 production |
| positive regulation of viral entry into host cell |
| positive regulation of monocyte differentiation |
| negative regulation of B cell apoptotic process |
| regulation of unsaturated fatty acid biosynthetic process |
| regulation of dendritic cell antigen processing and presentation |
| positive thymic T cell selection |
| negative thymic T cell selection |
| regulation of chemokine (C-X-C motif) ligand 2 production |
| positive regulation of interleukin-8 biosynthetic process |
| negative T cell selection |
| positive regulation of chemokine biosynthetic process |
| vacuole |
| regulation of macrophage cytokine production |
| nitric-oxide synthase binding |
| positive regulation of interleukin-6 biosynthetic process |
| regulation of chemokine biosynthetic process |
| negative regulation of DNA damage response, signal transduction by p53 class mediator |
| MHC class II protein complex |
| regulation of interleukin-8 biosynthetic process |
| positive regulation of type 2 immune response |
| MHC class II protein complex binding |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| regulation of B cell apoptotic process |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| regulation of monocyte differentiation |
| prostanoid biosynthetic process |
| positive regulation of fatty acid biosynthetic process |
| prostaglandin biosynthetic process |
| positive regulation of myeloid leukocyte cytokine production involved in immune response |
| thymic T cell selection |
| regulation of antigen processing and presentation |
| antigen processing and presentation of endogenous antigen |
| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| protein folding chaperone |
| regulation of interleukin-6 biosynthetic process |
| positive regulation of neutrophil chemotaxis |
| positive regulation of granulocyte chemotaxis |
| positive T cell selection |
| negative regulation of lymphocyte apoptotic process |
| positive regulation of neutrophil migration |
| regulation of neutrophil chemotaxis |
| integral component of lumenal side of endoplasmic reticulum membrane |
| regulation of viral entry into host cell |
| regulation of type 2 immune response |
| regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| multivesicular body |
| negative regulation of signal transduction by p53 class mediator |
| protein heterotetramerization |
| chaperone cofactor-dependent protein refolding |
| clathrin-coated endocytic vesicle membrane |
| positive regulation of fatty acid metabolic process |
| prostanoid metabolic process |
| prostaglandin metabolic process |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| regulation of neutrophil migration |
| de novo posttranslational protein folding |
| T cell selection |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| cytokine binding |
| positive regulation of B cell proliferation |
| de novo protein folding |
| transport vesicle membrane |
| unsaturated fatty acid biosynthetic process |
| regulation of granulocyte chemotaxis |
| negative regulation of T cell differentiation |
| regulation of fatty acid biosynthetic process |
| negative regulation of leukocyte apoptotic process |
| icosanoid biosynthetic process |
| T cell differentiation in thymus |
| cytokine receptor activity |
| positive regulation of interleukin-8 production |
| positive regulation of fibroblast proliferation |
| positive regulation of cytokine-mediated signaling pathway |
| regulation of lymphocyte apoptotic process |
| regulation of macrophage activation |
| negative regulation of lymphocyte differentiation |
| ER to Golgi transport vesicle membrane |
| positive regulation of cytokine production involved in immune response |
| protein trimerization |
| positive regulation of myeloid leukocyte differentiation |
| positive regulation of chemokine production |
| positive regulation of response to cytokine stimulus |
| chaperone-mediated protein folding |
| regulation of B cell proliferation |
| positive regulation of viral life cycle |
| positive regulation of cytokine biosynthetic process |
| endocytic vesicle membrane |
| regulation of interleukin-8 production |
| regulation of chemokine production |
| positive regulation of lipid biosynthetic process |
| negative regulation of response to DNA damage stimulus |
| regulation of fibroblast proliferation |
| amyloid-beta binding |
| regulation of leukocyte apoptotic process |
| positive regulation of T cell differentiation |
| regulation of cytokine production involved in immune response |
| regulation of fatty acid metabolic process |
| positive regulation of leukocyte chemotaxis |
| fatty acid derivative biosynthetic process |
| positive regulation of myeloid cell differentiation |
| trans-Golgi network membrane |
| positive regulation of lymphocyte differentiation |
| lysosomal lumen |
| positive regulation of interleukin-6 production |
| negative regulation of intrinsic apoptotic signaling pathway |
| positive regulation of production of molecular mediator of immune response |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| negative regulation of leukocyte differentiation |
| regulation of cytokine biosynthetic process |
| unsaturated fatty acid metabolic process |
| protein heterooligomerization |
| positive regulation of viral process |
| negative regulation of T cell activation |
| icosanoid metabolic process |
| regulation of leukocyte chemotaxis |
| regulation of myeloid leukocyte differentiation |
| fatty acid biosynthetic process |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of leukocyte migration |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| T cell differentiation |
| positive regulation of chemotaxis |
| negative regulation of hemopoiesis |
| positive regulation of leukocyte proliferation |
| positive regulation of small molecule metabolic process |
| regulation of T cell differentiation |
| negative regulation of peptide secretion |
| regulation of interleukin-6 production |
| regulation of production of molecular mediator of immune response |
| positive regulation of lipid metabolic process |
| regulation of viral life cycle |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| protein tetramerization |
| activation of MAPK activity |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of cytokine-mediated signaling pathway |
| fatty acid derivative metabolic process |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| regulation of cellular ketone metabolic process |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| regulation of response to cytokine stimulus |
| antigen processing and presentation of exogenous peptide antigen |
| regulation of signal transduction by p53 class mediator |
| antigen processing and presentation of exogenous antigen |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| monocarboxylic acid biosynthetic process |
| regulation of lipid biosynthetic process |
| positive regulation of hemopoiesis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| antigen processing and presentation of peptide antigen |
| regulation of leukocyte migration |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| regulation of viral process |
| immunoglobulin mediated immune response |
| regulation of B cell activation |
| B cell mediated immunity |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| positive regulation of leukocyte cell-cell adhesion |
| antigen processing and presentation |
| regulation of response to DNA damage stimulus |
| positive regulation of immune effector process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of leukocyte proliferation |
| negative regulation of apoptotic signaling pathway |
| regulation of myeloid cell differentiation |
| protein folding |
| negative regulation of secretion |
| T cell activation |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| lymphocyte differentiation |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| negative regulation of cell migration |
| positive regulation of MAP kinase activity |
| lymphocyte mediated immunity |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cell motility |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| lysosomal membrane |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| negative regulation of cellular component movement |
| regulation of T cell activation |
| fatty acid metabolic process |
| negative regulation of locomotion |
| activation of protein kinase activity |
| leukocyte differentiation |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| positive regulation of lymphocyte activation |
| leukocyte migration |
| lymphocyte activation |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of small molecule metabolic process |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of immune effector process |
| negative regulation of transport |
| regulation of peptide secretion |
| positive regulation of cell migration |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| protein complex oligomerization |
| positive regulation of cell motility |
| monocarboxylic acid metabolic process |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| cell population proliferation |
| hemopoiesis |
| positive regulation of kinase activity |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| protein-containing complex |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| cell surface |
| Golgi membrane |
| regulation of cell activation |
| immune system development |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of cytokine production |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of MAPK cascade |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of cell migration |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| leukocyte activation |
| negative regulation of developmental process |
| cellular lipid metabolic process |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| negative regulation of cell death |
| intracellular protein transport |
| regulation of cellular component movement |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| locomotion |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Tunicamycin 0.04μM R07 exp418 | -1.82 |
| Ethanol 0.01 R05 exp234 | -1.77 |
| Trimetrexate 0.03μM R08 exp535 | -1.75 |
| Milciclib 2μM R08 exp502 | -1.74 |
| Thalidomide 20μM R07 exp406 | 2.18 |
| Pomalidomide 20μM R07 exp391 | 2.31 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10935
- Expression level (log2 read counts): 10.05
Expression Distribution
CD74 Expression in NALM6 Cells: 10.05
