NEFM [The Human Chemical-Genetic Interaction Map Project]

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======= NEFM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEFM
  * **<color #00a2e8>Official Name</color>**: neurofilament medium
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4741|4741]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07197|P07197]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEFM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEFM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
|Filament head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurofilament bundle assembly|
|neurofibrillary tangle|
|intermediate filament bundle assembly|
|neurofilament|
|intermediate filament organization|
|intermediate filament cytoskeleton|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|structural constituent of cytoskeleton|
|microtubule binding|
|axon|
|supramolecular fiber organization|
|cytoskeleton organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.85|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.37|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.18|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.97|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.88|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.84|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.82|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.75|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.72|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.73|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.77|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.78|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.8|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.88|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.01|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.03|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.03|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.1|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.42|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3866
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEFM Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>