HSD3B1

Official Symbol: HSD3B1
Official Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Aliases and Previous Symbols: N/A
Entrez ID: 3283
UniProt: P14060
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016].
UniProt Summary: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. {ECO:0000269|PubMed:1401999, ECO:0000269|PubMed:2139411}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

5alpha-androstane-3beta,17beta-diol dehydrogenase activity
cholesterol dehydrogenase activity
steroid delta-isomerase activity
3-keto sterol reductase activity
3-beta-hydroxy-delta5-steroid dehydrogenase activity
mineralocorticoid biosynthetic process
mineralocorticoid metabolic process
smooth endoplasmic reticulum membrane
androgen biosynthetic process
glucocorticoid biosynthetic process
estrogen biosynthetic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
glucocorticoid metabolic process
response to corticosterone
androgen metabolic process
C21-steroid hormone metabolic process
response to mineralocorticoid
estrogen metabolic process
steroid hormone biosynthetic process
hormone biosynthetic process
mitochondrial intermembrane space
hippocampus development
limbic system development
oxidoreductase activity
cellular hormone metabolic process
steroid biosynthetic process
response to glucocorticoid
response to corticosteroid
pallium development
response to ketone
hormone metabolic process
response to alcohol
telencephalon development
steroid metabolic process
response to steroid hormone
forebrain development
mitochondrial inner membrane
regulation of hormone levels
lipid biosynthetic process
intracellular membrane-bounded organelle