HSD3B1 [The Human Chemical-Genetic Interaction Map Project]

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======= HSD3B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSD3B1
  * **<color #00a2e8>Official Name</color>**: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3283|3283]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14060|P14060]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSD3B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSD3B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109715|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. {ECO:0000269|PubMed:1401999, ECO:0000269|PubMed:2139411}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|3Beta HSD|
|adh short|
|RmlD sub bind|
|NAD binding 4|
|Polysacc synt 2|
|Epimerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|
|cholesterol dehydrogenase activity|
|steroid delta-isomerase activity|
|3-keto sterol reductase activity|
|3-beta-hydroxy-delta5-steroid dehydrogenase activity|
|mineralocorticoid biosynthetic process|
|mineralocorticoid metabolic process|
|smooth endoplasmic reticulum membrane|
|androgen biosynthetic process|
|glucocorticoid biosynthetic process|
|estrogen biosynthetic process|
|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|
|glucocorticoid metabolic process|
|response to corticosterone|
|androgen metabolic process|
|C21-steroid hormone metabolic process|
|response to mineralocorticoid|
|estrogen metabolic process|
|steroid hormone biosynthetic process|
|hormone biosynthetic process|
|mitochondrial intermembrane space|
|hippocampus development|
|limbic system development|
|oxidoreductase activity|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|response to glucocorticoid|
|response to corticosteroid|
|pallium development|
|response to ketone|
|hormone metabolic process|
|response to alcohol|
|telencephalon development|
|steroid metabolic process|
|response to steroid hormone|
|forebrain development|
|mitochondrial inner membrane|
|regulation of hormone levels|
|lipid biosynthetic process|
|intracellular membrane-bounded organelle|
|brain development|
|head development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|central nervous system development|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.76|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.8|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.87|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.88|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16895
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSD3B1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>