FTY720 3μM R08 exp483 [The Human Chemical-Genetic Interaction Map Project]

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====== FTY720 3μM R08 exp483 ======
==== Mechanism of Action ====
Agonist of sphingosine 1-phosphate receptor-1 (S1P1), derived from myriocin
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolic Enzyme Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Fingolimod hydrochloride%%
    * **<color #00a2e8>Synonyms:</color>** FTY720
    * **<color #00a2e8>CAS #:</color>** 162359-56-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/107969|107969]]
    * **<color #00a2e8>IUPAC:</color>** %%2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
    * **<color #00a2e8>INCHI Key:</color>** SWZTYAVBMYWFGS-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 343.9
    * **<color #00a2e8>Canonical SMILES:</color>** CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL
{{:chemogenomics:structures:chem-0292.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** In house - University of Montreal - Hanessian/Thibault Lab
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** FTY720
    * **<color #00a2e8>Min:</color>** 0.9763; **<color #00a2e8>Max:</color>** 99.8512
{{:chemogenomics:dose_response:dr_538.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |2.6080    |
| IC20  |3.1270    |
| IC30  |3.5270    |
| IC40  |3.8940    |
| IC50  |4.2640    |
| IC60  |4.6690    |
| IC70  |5.1540    |
| IC80  |5.8150    |
| IC90  |6.9720    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 3µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.9
    * **<color #00a2e8>Numbers of reads</color>**: 16484616


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|17/1|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/FTY720_3uM_Round-8_exp483.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='FTY720 3μM R08 exp483'>
{{:chemogenomics:cranks_plots:exp483.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SLC5A3|SLC5A3]]|-5.15|<0.01|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-4.01|<0.01|
|[[:human_genes:C:CHKA|CHKA]]|-3.57|<0.01|
|[[:human_genes:S:SCYL1|SCYL1]]|-3.55|<0.01|
|[[:human_genes:H:HSD17B12|HSD17B12]]|-3.34|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-3.30|<0.01|
|[[:human_genes:A:ARL1|ARL1]]|-3.01|<0.01|
|[[:human_genes:B:BRD1|BRD1]]|-2.98|<0.01|
|[[:human_genes:F:FDPS|FDPS]]|-2.85|0.01|
|[[:human_genes:S:SCD|SCD]]|-2.77|0.02|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.70|0.02|
|[[:human_genes:F:FDFT1|FDFT1]]|-2.69|0.01|
|[[:human_genes:S:SLC25A1|SLC25A1]]|-2.59|0.02|
|[[:human_genes:A:AGPAT2|AGPAT2]]|-2.56|0.04|
|[[:human_genes:C:COMMD5|COMMD5]]|-2.55|0.02|
|[[:human_genes:D:DOT1L|DOT1L]]|-2.50|0.02|
|[[:human_genes:C:CERS2|CERS2]]|-2.40|0.04|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.39|0.09|
|[[:human_genes:G:GMPPB|GMPPB]]|-2.33|0.48|
|[[:human_genes:R:RAB7A|RAB7A]]|-2.33|0.06|
|[[:human_genes:F:FGFBP2|FGFBP2]]|-2.31|0.10|
|[[:human_genes:A:ADSL|ADSL]]|-2.29|0.22|
|[[:human_genes:X:XPO5|XPO5]]|-2.25|0.18|
|[[:human_genes:C:CCND2|CCND2]]|-2.23|0.12|
|[[:human_genes:U:UBE2A|UBE2A]]|-2.22|0.10|
|[[:human_genes:A:ACSL4|ACSL4]]|-2.21|0.13|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.20|0.10|
|[[:human_genes:I:IRGQ|IRGQ]]|-2.19|0.10|
|[[:human_genes:L:LZTS3|LZTS3]]|-2.19|0.10|
|[[:human_genes:P:PTPN23|PTPN23]]|-2.16|0.21|
|[[:human_genes:C:C1QL1|C1QL1]]|1.99|0.34|
|[[:human_genes:M:MYCBP2|MYCBP2]]|1.99|0.56|
|[[:human_genes:K:KPTN|KPTN]]|2.01|0.33|
|[[:human_genes:W:WDFY2|WDFY2]]|2.02|0.42|
|[[:human_genes:H:HSD3B1|HSD3B1]]|2.02|0.32|
|[[:human_genes:S:SLU7|SLU7]]|2.05|0.72|
|[[:human_genes:T:TRIM3|TRIM3]]|2.06|0.27|
|[[:human_genes:R:RMND1|RMND1]]|2.06|0.27|
|[[:human_genes:L:LHFP|LHFP]]|2.07|0.27|
|[[:human_genes:G:GOT2|GOT2]]|2.07|0.27|
|[[:human_genes:P:PREPL|PREPL]]|2.07|0.27|
|[[:human_genes:C:CHD7|CHD7]]|2.08|0.34|
|[[:human_genes:G:GID8|GID8]]|2.08|0.27|
|[[:human_genes:T:TMEM240|TMEM240]]|2.09|0.27|
|[[:human_genes:S:SCGN|SCGN]]|2.10|0.27|
|[[:human_genes:I:ITFG2|ITFG2]]|2.14|0.27|
|[[:human_genes:L:LEUTX|LEUTX]]|2.15|0.56|
|[[:human_genes:Z:ZNF469|ZNF469]]|2.23|0.24|
|[[:human_genes:R:RABGAP1|RABGAP1]]|2.27|0.22|
|[[:human_genes:U:UTP20|UTP20]]|2.32|0.42|
|[[:human_genes:Z:ZC3HAV1L|ZC3HAV1L]]|2.33|0.25|
|[[:human_genes:C:CDC45|CDC45]]|2.36|0.56|
|[[:human_genes:P:POLR2B|POLR2B]]|2.39|0.34|
|[[:human_genes:M:MTERF|MTERF]]|2.39|0.15|
|[[:human_genes:R:RAD21|RAD21]]|2.48|0.25|
|[[:human_genes:R:RDX|RDX]]|2.48|0.10|
|[[:human_genes:S:SHMT2|SHMT2]]|2.58|0.22|
|[[:human_genes:P:PDCD7|PDCD7]]|2.59|0.08|
|[[:human_genes:S:SPHK2|SPHK2]]|2.84|0.05|
|[[:human_genes:M:MCUR1|MCUR1]]|2.89|0.06|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.107|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.098|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.091|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|0.082|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.08|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|0.066|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|0.059|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.059|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp433|LJH685 50μM R08 exp433]]|0.058|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|0.057|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|0.056|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.056|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp504|MK2206 4μM R08 exp504]]|0.055|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|0.052|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.052|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|0.051|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.121|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|0.093|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.083|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.079|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|0.077|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.077|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.076|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|0.075|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.074|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp218|A-395 10μM R05 exp218]]|0.052|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.052|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.051|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.051|<button type="primary" size="small" modal="29">View</button>|
</modal>


<modal id="1" size="lg" title="FTY720 3μM R08 exp483  vs  NN-Dimethylsphingosine 2.5μM R08 exp508">
{{:chemogenomics:comparison_plots:exp483_vs_exp508.png?nolink |}}
</modal>

<modal id="2" size="lg" title="FTY720 3μM R08 exp483  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp483_vs_exp530.png?nolink |}}
</modal>

<modal id="3" size="lg" title="FTY720 3μM R08 exp483  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp442_vs_exp483.png?nolink |}}
</modal>

<modal id="4" size="lg" title="FTY720 3μM R08 exp483  vs  Hydroxychloroquine 30μM R08 exp490">
{{:chemogenomics:comparison_plots:exp483_vs_exp490.png?nolink |}}
</modal>

<modal id="5" size="lg" title="FTY720 3μM R08 exp483  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp483.png?nolink |}}
</modal>

<modal id="6" size="lg" title="FTY720 3μM R08 exp483  vs  Nicotine 3000μM R08 exp510">
{{:chemogenomics:comparison_plots:exp483_vs_exp510.png?nolink |}}
</modal>

<modal id="7" size="lg" title="FTY720 3μM R08 exp483  vs  UNC1999 2μM R03 exp155">
{{:chemogenomics:comparison_plots:exp155_vs_exp483.png?nolink |}}
</modal>

<modal id="8" size="lg" title="FTY720 3μM R08 exp483  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp483.png?nolink |}}
</modal>

<modal id="9" size="lg" title="FTY720 3μM R08 exp483  vs  LJH685 50μM R08 exp433">
{{:chemogenomics:comparison_plots:exp433_vs_exp483.png?nolink |}}
</modal>

<modal id="10" size="lg" title="FTY720 3μM R08 exp483  vs  SGC0946 7μM R03 exp151">
{{:chemogenomics:comparison_plots:exp151_vs_exp483.png?nolink |}}
</modal>

<modal id="11" size="lg" title="FTY720 3μM R08 exp483  vs  Vemurafenib 6.6μM R02 exp89">
{{:chemogenomics:comparison_plots:exp483_vs_exp89.png?nolink |}}
</modal>

<modal id="12" size="lg" title="FTY720 3μM R08 exp483  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp483_vs_exp77.png?nolink |}}
</modal>

<modal id="13" size="lg" title="FTY720 3μM R08 exp483  vs  MK2206 4μM R08 exp504">
{{:chemogenomics:comparison_plots:exp483_vs_exp504.png?nolink |}}
</modal>

<modal id="14" size="lg" title="FTY720 3μM R08 exp483  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp182_vs_exp483.png?nolink |}}
</modal>

<modal id="15" size="lg" title="FTY720 3μM R08 exp483  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp483.png?nolink |}}
</modal>

<modal id="16" size="lg" title="FTY720 3μM R08 exp483  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp483_vs_exp79.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp344_vs_exp483.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Chloroquine 32μM R08 exp470  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp470_vs_exp483.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Bafilomycin-A1 0.009μM R08 exp454  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp454_vs_exp483.png?nolink |}}
</modal>

<modal id="20" size="lg" title="BS-181 20μM R08 exp461  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp461_vs_exp483.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Azithromycin 100μM R08 exp452  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp452_vs_exp483.png?nolink |}}
</modal>

<modal id="22" size="lg" title="B02 10μM R08 exp453  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp453_vs_exp483.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Bisphenol F 50μM R08 exp457  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp457_vs_exp483.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Clomiphene 4.4μM R02 exp68  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp483_vs_exp68.png?nolink |}}
</modal>

<modal id="25" size="lg" title="EPZ-5676 30μM R05 exp233  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp233_vs_exp483.png?nolink |}}
</modal>

<modal id="26" size="lg" title="A-395 10μM R05 exp218  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp218_vs_exp483.png?nolink |}}
</modal>

<modal id="27" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp445_vs_exp483.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp227_vs_exp483.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Cannabidiol 20μM R08 exp466  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp466_vs_exp483.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|fatty-acyl-CoA biosynthetic process|71.01|HSD17B12,SLC25A1,ACSL4|
|lipid biosynthetic process|10.33|CHKA,HSD17B12,FDPS,SCD,FDFT1,SLC25A1,AGPAT2,CERS2,ACSL4,PCYT1A|
|organophosphate biosynthetic process|9.17|CHKA,HSD17B12,FDPS,SLC25A1,AGPAT2,ADSL,ACSL4,PCYT1A|
|cellular lipid metabolic process|6.71|CHKA,HSD17B12,FDPS,SCD,DPAGT1,FDFT1,AGPAT2,CERS2,ACSL4,PCYT1A|
|organophosphate metabolic process|6.19|CHKA,HSD17B12,FDPS,FDFT1,SLC25A1,AGPAT2,ADSL,ACSL4,PCYT1A|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>