IREB2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CoCl2 18μM R07 exp346	-2.62
Hydroxyurea 100μM R07 exp329	-2.6
Dimethyloxaloylglycine 100μM R05 exp229	-2.45
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.38
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.29
Diepoxybutane 3μM R07 exp354	-2.03
Resveratrol 16μM R03 exp147	-2.01
42°C R08 exp539	-1.83
Cyclosporin-A 0.8μM R07 exp347	-1.77
THZ531 0.11μM R07 exp409	1.77
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.12
Olaparib 4μM R08 exp512	2.38
Epigallocatechin gallate 20μM R05 exp230	2.76
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.93

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
HGC6.3	0.517
ANKH	0.429

Aconitase
Aconitase C

iron-responsive element binding
aconitate hydratase activity
citrate metabolic process
protoporphyrinogen IX biosynthetic process
protoporphyrinogen IX metabolic process
translation repressor activity
tricarboxylic acid metabolic process
heme biosynthetic process
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
heme metabolic process
intestinal absorption
tricarboxylic acid cycle
porphyrin-containing compound metabolic process
4 iron, 4 sulfur cluster binding
osteoclast differentiation
pigment biosynthetic process
tetrapyrrole metabolic process
cellular iron ion homeostasis
pigment metabolic process
iron ion transport
digestive system process
aerobic respiration
iron ion homeostasis
erythrocyte homeostasis
post-embryonic development
antibiotic metabolic process
cellular transition metal ion homeostasis
myeloid cell homeostasis
myeloid leukocyte differentiation
digestion
transition metal ion transport
negative regulation of translation
transition metal ion homeostasis
negative regulation of cellular amide metabolic process
cellular respiration
homeostasis of number of cells
cofactor biosynthetic process
myeloid cell differentiation
energy derivation by oxidation of organic compounds