ABCC4

Entrez Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014].
UniProt Summary: May be an organic anion pump relevant to cellular detoxification.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Amiloride 100μM R08 exp447	-5.44
Dimethyloxaloylglycine 100μM R05 exp229	-4.25
Adefovir 20μM R07 exp332	-3.24
Dimethyloxaloylglycine 11μM R07 exp314	-2.48
Fluvastatin 2.2μM R06 exp282	-2.05
AICAR 240μM R03 exp116	-1.79
MS023 7μM R03 exp135	-1.76
Deguelin 0.15μM R05 exp209	1.71
Ribavirin 10 to 15μM on day4 R04 exp160	1.84
Trimetrexate 0.03μM R08 exp535	8.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ABC tran
ABC membrane

ion transmembrane transporter activity, phosphorylative mechanism
15-hydroxyprostaglandin dehydrogenase (NAD+) activity
prostaglandin secretion
platelet dense granule membrane
prostaglandin transport
icosanoid secretion
fatty acid derivative transport
icosanoid transport
ATPase-coupled transmembrane transporter activity
fatty acid transport
acid secretion
positive regulation of smooth muscle cell proliferation
platelet degranulation
regulation of smooth muscle cell proliferation
monocarboxylic acid transport
basolateral plasma membrane
ATPase activity
organic acid transport
carboxylic acid transport
lipid transport
lipid localization
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
organic anion transport
anion transport
regulated exocytosis
organelle assembly
exocytosis
positive regulation of cell population proliferation
response to organic cyclic compound
ion transmembrane transport
oxidation-reduction process
response to organonitrogen compound
secretion by cell
response to drug
export from cell
response to nitrogen compound
plasma membrane bounded cell projection organization