HMG20A

Gene Information

Official Symbol: HMG20A
Official Name: high mobility group 20A
Aliases and Previous Symbols: N/A
Entrez ID: 10363
UniProt: Q9NP66
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15975
Expression level (log2 read counts): 5.8

Expression Distribution

Screen	Score
PNU96415E 10μM R03 exp145	-1.8
AICAR 240μM R05 exp211	1.78
Arsenate 40μM R06 exp264	2.53
Dimethyloxaloylglycine 100μM R05 exp229	2.55

negative regulation of protein sumoylation
regulation of protein sumoylation
negative regulation of protein modification by small protein conjugation or removal
negative regulation of neuron differentiation
regulation of protein modification by small protein conjugation or removal
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
protein heterodimerization activity
negative regulation of protein modification process
regulation of neuron differentiation
DNA-binding transcription factor activity
chromatin organization
negative regulation of cell differentiation
regulation of neurogenesis
negative regulation of transcription by RNA polymerase II
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
negative regulation of cellular protein metabolic process
chromosome organization
identical protein binding
negative regulation of protein metabolic process
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
negative regulation of gene expression
regulation of cell differentiation
regulation of protein modification process