SLC16A7

Entrez Summary: N/A
UniProt Summary: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. {ECO:0000269|PubMed:9786900}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dimethyloxaloylglycine 11μM R07 exp314	1.96
Dimethyloxaloylglycine 100μM R05 exp229	6.82

Gene	Correlation
ARNT	0.42
RUVBL2	0.411

pyruvate secondary active transmembrane transporter activity
pyruvate transmembrane transport
pyruvate transmembrane transporter activity
pyruvate transport
lactate transmembrane transporter activity
lactate transport
lactate transmembrane transport
monocarboxylic acid transmembrane transporter activity
symporter activity
carboxylic acid transmembrane transport
organic acid transmembrane transport
monocarboxylic acid transport
organic hydroxy compound transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
organic anion transport
anion transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane