ZNF148 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF148 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF148
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 148
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7707|7707]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQR1|Q9UQR1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF148&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF148|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601897|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|substantia nigra development|
|cellular defense response|
|neural nucleus development|
|midbrain development|
|transcription regulatory region DNA binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|sequence-specific DNA binding|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|gamete generation|
|brain development|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|central nervous system development|
|Golgi apparatus|
|multi-organism reproductive process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.67|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.02|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.98|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.94|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.92|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.9|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.84|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.81|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.75|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.74|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.72|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.7|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.71|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.73|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.74|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.74|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.77|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.81|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.85|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.85|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.86|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.91|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.93|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.01|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.02|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.05|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.11|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.11|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.21|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.26|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.58|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.7|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnf113a|RNF113A]]|0.51|
|[[:human genes:s:setd1a|SETD1A]]|0.477|
|[[:human genes:n:nufip2|NUFIP2]]|0.465|
|[[:human genes:m:memo1|MEMO1]]|0.459|
|[[:human genes:c:cdc73|CDC73]]|0.459|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.458|
|[[:human genes:e:eif4b|EIF4B]]|0.456|
|[[:human genes:p:paf1|PAF1]]|0.455|
|[[:human genes:i:iscu|ISCU]]|0.452|
|[[:human genes:e:exosc6|EXOSC6]]|0.449|
|[[:human genes:c:cdk8|CDK8]]|0.448|
|[[:human genes:o:orc6|ORC6]]|0.446|
|[[:human genes:f:fam122a|FAM122A]]|0.445|
|[[:human genes:t:tfip11|TFIP11]]|0.441|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.438|
|[[:human genes:n:nup85|NUP85]]|0.43|
|[[:human genes:r:rbm39|RBM39]]|0.428|
|[[:human genes:n:nup160|NUP160]]|0.423|
|[[:human genes:p:plrg1|PLRG1]]|0.414|
|[[:human genes:t:tagln|TAGLN]]|0.411|
|[[:human genes:s:sap30bp|SAP30BP]]|0.41|
|[[:human genes:e:eif3g|EIF3G]]|0.41|
|[[:human genes:r:rsf1|RSF1]]|0.41|
|[[:human genes:c:cdc6|CDC6]]|0.408|
|[[:human genes:b:bod1l1|BOD1L1]]|0.406|
|[[:human genes:c:cactin|CACTIN]]|0.406|
|[[:human genes:p:prim1|PRIM1]]|0.405|
|[[:human genes:c:cdc5l|CDC5L]]|0.405|
|[[:human genes:c:chd4|CHD4]]|0.404|
|[[:human genes:k:kdm6a|KDM6A]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF148 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>