RPL8 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL8
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6132|6132]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62917|P62917]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604177|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the large ribosomal subunit. {ECO:0000305|PubMed:12962325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L2|
|Ribosomal L2 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polysomal ribosome|
|rRNA binding|
|cytosolic large ribosomal subunit|
|cytoplasmic translation|
|postsynapse|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|postsynaptic density|
|establishment of protein localization to membrane|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-3.26|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-3.03|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.3|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.23|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.06|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.04|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.96|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.72|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.7|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.7|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.75|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.76|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.83|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.9|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.95|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.96|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.97|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.97|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.01|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.03|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.03|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.1|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.14|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.2|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.21|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.24|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.25|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.28|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.28|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.4|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.45|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.69|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.71|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|3.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.489|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.469|
|[[:human genes:p:psmc5|PSMC5]]|0.458|
|[[:human genes:r:rpl35|RPL35]]|0.456|
|[[:human genes:a:adrm1|ADRM1]]|0.451|
|[[:human genes:r:rfc1|RFC1]]|0.445|
|[[:human genes:p:psmc1|PSMC1]]|0.443|
|[[:human genes:n:narfl|NARFL]]|0.441|
|[[:human genes:p:ppm1d|PPM1D]]|0.44|
|[[:human genes:v:vps28|VPS28]]|0.44|
|[[:human genes:p:psmb4|PSMB4]]|0.438|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.436|
|[[:human genes:n:nelfa|NELFA]]|0.433|
|[[:human genes:p:psma7|PSMA7]]|0.432|
|[[:human genes:t:tspy8|TSPY8]]|0.43|
|[[:human genes:u:utp3|UTP3]]|0.425|
|[[:human genes:c:cdc73|CDC73]]|0.422|
|[[:human genes:v:vasn|VASN]]|0.42|
|[[:human genes:s:supt5h|SUPT5H]]|0.417|
|[[:human genes:m:mbtd1|MBTD1]]|0.416|
|[[:human genes:p:psma6|PSMA6]]|0.416|
|[[:human genes:p:psmd11|PSMD11]]|0.415|
|[[:human genes:p:psmd1|PSMD1]]|0.414|
|[[:human genes:b:brd2|BRD2]]|0.413|
|[[:human genes:n:nup160|NUP160]]|0.406|
|[[:human genes:f:fam160a1|FAM160A1]]|0.405|
|[[:human genes:r:rps12|RPS12]]|0.404|
|[[:human genes:c:chmp4b|CHMP4B]]|0.403|
|[[:human genes:o:or10g3|OR10G3]]|0.402|
|[[:human genes:d:dtl|DTL]]|0.402|
|[[:human genes:c:cdca3|CDCA3]]|0.401|
|[[:human genes:p:polr1b|POLR1B]]|0.401|
|[[:human genes:e:exosc9|EXOSC9]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL8 Expression in NALM6 Cells: 9.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>