UNC2400 2μM R03 exp156 [The Human Chemical-Genetic Interaction Map Project]

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====== UNC2400 2μM R03 exp156 ======
==== Mechanism of Action ====
Inactive control for UNC1999 (EZH2 inhibitor)
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N-[(1,6-Dimethyl-2-oxo-4-propylpyridin-3-yl)methyl]-N-methyl-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1433200-49-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/91691116|91691116]]
    * **<color #00a2e8>IUPAC:</color>** %%N-[(1,6-dimethyl-2-oxo-4-propylpyridin-3-yl)methyl]-N-methyl-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C35H47N7O2/c1-9-10-26-17-25(6)39(8)35(44)31(26)22-38(7)34(43)29-18-28(19-32-30(29)21-37-42(32)24(4)5)27-11-12-33(36-20-27)41-15-13-40(14-16-41)23(2)3/h11-12,17-21,23-24H,9-10,13-16,22H2,1-8H3
    * **<color #00a2e8>INCHI Key:</color>** IFSQHIRDVVFJSQ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 597.8
    * **<color #00a2e8>Canonical SMILES:</color>** CCCC1=C(C(=O)N(C(=C1)C)C)CN(C)C(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C35H47N7O2
{{:chemogenomics:structures:chem-0107.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Structural Genomics Consortium
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C35H47N7O2 598.3864; found 598.38856
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** UNC2400
    * **<color #00a2e8>Min:</color>** -2.6809; **<color #00a2e8>Max:</color>** 49.0595
{{:chemogenomics:dose_response:dr_161.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |2.1354    |
| IC30  |6.8765    |
| IC40  |17.9352    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 2µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.9
    * **<color #00a2e8>Numbers of reads</color>**: 10345192


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/UNC2400_2uM_Round-3_exp156.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='UNC2400 2μM R03 exp156'>
{{:chemogenomics:cranks_plots:exp156.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:C:CDIPT|CDIPT]]|-3.59|0.30|
|[[:human_genes:K:KDSR|KDSR]]|-2.54|0.29|
|[[:human_genes:P:PEX6|PEX6]]|-2.35|0.30|
|[[:human_genes:C:CMTR1|CMTR1]]|-2.34|0.36|
|[[:human_genes:P:PLEKHD1|PLEKHD1]]|-2.26|0.36|
|[[:human_genes:U:UTF1|UTF1]]|-2.21|0.36|
|[[:human_genes:N:NQO1|NQO1]]|-2.16|0.74|
|[[:human_genes:S:SLC12A2|SLC12A2]]|-2.10|0.74|
|[[:human_genes:R:RGP1|RGP1]]|-2.05|0.74|
|[[:human_genes:V:VARS|VARS]]|-2.04|0.85|
|[[:human_genes:K:KTN1|KTN1]]|-2.02|0.74|
|[[:human_genes:Z:ZNF180|ZNF180]]|-2.00|0.74|
|[[:human_genes:P:PTAR1|PTAR1]]|-2.00|0.74|
|[[:human_genes:M:MUC5B|MUC5B]]|-1.98|0.74|
|[[:human_genes:F:FAM60A|FAM60A]]|-1.97|0.74|
|[[:human_genes:C:CCDC22|CCDC22]]|-1.96|0.74|
|[[:human_genes:P:PMVK|PMVK]]|-1.95|0.74|
|[[:human_genes:S:SUMO2|SUMO2]]|-1.94|0.84|
|[[:human_genes:G:GOT2|GOT2]]|-1.93|0.74|
|[[:human_genes:U:UHRF1|UHRF1]]|-1.93|0.74|
|[[:human_genes:A:ADARB1|ADARB1]]|-1.91|0.74|
|[[:human_genes:T:TUBB6|TUBB6]]|-1.90|0.74|
|[[:human_genes:F:FOXI1|FOXI1]]|-1.86|0.74|
|[[:human_genes:S:SEPT3|SEPT3]]|-1.86|0.74|
|[[:human_genes:R:RBM14|RBM14]]|-1.85|0.84|
|[[:human_genes:N:NSFL1C|NSFL1C]]|-1.85|0.74|
|[[:human_genes:G:GCLC|GCLC]]|-1.85|0.74|
|[[:human_genes:R:RPP21|RPP21]]|-1.84|0.74|
|[[:human_genes:R:RBM14-RBM4|RBM14-RBM4]]|-1.83|0.84|
|[[:human_genes:Z:ZP1|ZP1]]|-1.83|0.74|
|[[:human_genes:D:DENND4C|DENND4C]]|1.88|0.75|
|[[:human_genes:D:DNAJC21|DNAJC21]]|1.88|0.75|
|[[:human_genes:D:DKK1|DKK1]]|1.90|0.75|
|[[:human_genes:P:PSMD13|PSMD13]]|1.93|0.75|
|[[:human_genes:D:DEFB118|DEFB118]]|1.93|0.75|
|[[:human_genes:S:SP8|SP8]]|1.93|0.75|
|[[:human_genes:C:C7orf31|C7orf31]]|1.96|0.75|
|[[:human_genes:G:GJA10|GJA10]]|1.96|0.75|
|[[:human_genes:C:CD300LF|CD300LF]]|1.96|0.75|
|[[:human_genes:T:TENC1|TENC1]]|1.97|0.75|
|[[:human_genes:R:RPL8|RPL8]]|1.97|0.76|
|[[:human_genes:O:OR51G1|OR51G1]]|1.97|0.75|
|[[:human_genes:C:CMYA5|CMYA5]]|1.99|0.75|
|[[:human_genes:R:RPS28|RPS28]]|2.00|0.78|
|[[:human_genes:G:GPSM3|GPSM3]]|2.01|0.75|
|[[:human_genes:A:ART4|ART4]]|2.04|0.75|
|[[:human_genes:P:POLA1|POLA1]]|2.06|0.78|
|[[:human_genes:B:BDH1|BDH1]]|2.10|0.59|
|[[:human_genes:B:BTBD9|BTBD9]]|2.10|0.75|
|[[:human_genes:R:RTN4|RTN4]]|2.10|0.59|
|[[:human_genes:S:SCAF11|SCAF11]]|2.13|0.75|
|[[:human_genes:P:POLD3|POLD3]]|2.14|0.78|
|[[:human_genes:C:COPZ1|COPZ1]]|2.17|0.75|
|[[:human_genes:Z:ZNF891|ZNF891]]|2.19|0.49|
|[[:human_genes:O:OR2T27|OR2T27]]|2.20|0.59|
|[[:human_genes:C:C18orf32|C18orf32]]|2.23|0.75|
|[[:human_genes:C:CRYGS|CRYGS]]|2.29|0.39|
|[[:human_genes:K:KRBOX4|KRBOX4]]|2.41|0.39|
|[[:human_genes:Q:QSER1|QSER1]]|2.41|0.39|
|[[:human_genes:U:USP37|USP37]]|2.68|0.39|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>