SP8

Entrez Summary: The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
UniProt Summary: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 0.07μM R08 exp431	-1.81
L-74142 5μM R03 exp131	1.7
OICR-9429 10μM R03 exp142	1.83
YM155 0.001μM R08 exp432	1.83
Dimethyloxaloylglycine 100μM R05 exp229	1.84
UNC2400 2μM R03 exp156	1.93
Nocodazole 0.1μM R03 exp94	2.02
Dihydrosphingosine 8μM R08 exp476	2.04
DABN racemic mixture R03 exp93	2.06
Nocodazole 0.2μM R02 exp64	2.06
Nicotinate 1000μM R03 exp140	2.18
Rotenone 2μM R00 exp33	2.59
Nocodazole 0.2μM R00 exp24	2.73

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

proximal/distal pattern formation
dorsal/ventral pattern formation
embryonic appendage morphogenesis
embryonic limb morphogenesis
appendage morphogenesis
limb morphogenesis
appendage development
limb development
regionalization
pattern specification process
embryonic morphogenesis
embryo development
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific