FAM60A

• Official Symbol: SINHCAF
• Official Name: SIN3-HDAC complex associated factor
• Aliases and Previous Symbols: N/A
• Entrez ID: 58516
• UniProt: Q9NP50
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: N/A
• UniProt Summary: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity). {ECO:0000250|UniProtKB:Q8C8M1, ECO:0000269|PubMed:22865885, ECO:0000269|PubMed:22984288}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 2942
• Expression level (log2 read counts): 7.23

Expression Distribution

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FAM60A Expression in NALM6 Cells: 7.23