KTN1

Entrez Summary: N/A
UniProt Summary: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UNC2400 2μM R03 exp156	-2.02
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.84
Prochlorperazine 5.2μM R02 exp77	-1.74
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.79
Momordin-Ic 10μM R08 exp506	1.92
A-395 10μM R05 exp218	2.2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

kinesin binding
microtubule-based movement
endoplasmic reticulum lumen
cadherin binding
post-translational protein modification
microtubule-based process
endoplasmic reticulum membrane
endoplasmic reticulum
RNA binding
integral component of plasma membrane
movement of cell or subcellular component
membrane