MUC5B

Gene Information

Official Symbol: MUC5B
Official Name: mucin 5B, oligomeric mucus/gel-forming
Aliases and Previous Symbols: N/A
Entrez ID: 727897
UniProt: Q9HC84
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0125461 0.74μM R02 exp84	-2.48
Rotenone 20μM R00 exp34	-2.07
PNU96415E 10μM R03 exp145	-2
UNC2400 2μM R03 exp156	-1.98
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.85
THZ531 0.11μM R07 exp409	-1.84
IU1-47 25μM R04 exp182	-1.81
Isonicotinamide 500μM R03 exp129	-1.71
NMS-873 0.07μM R07 exp380	1.81
Momordin-Ic 10μM R08 exp506	1.84

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6238
Expression level (log2 read counts): -4.27

Expression Distribution

C8
VWC
VWD
TIL

O-glycan processing
Golgi lumen
protein O-linked glycosylation
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
innate immune response-activating signal transduction
activation of innate immune response
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
positive regulation of innate immune response
positive regulation of response to biotic stimulus
glycoprotein metabolic process
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
carbohydrate derivative biosynthetic process
activation of immune response
intracellular membrane-bounded organelle
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
carbohydrate derivative metabolic process
regulation of response to external stimulus
regulation of immune response
positive regulation of immune system process
organonitrogen compound biosynthetic process
regulation of response to stress
extracellular space
regulation of immune system process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process