PPWD1

Entrez Summary: N/A
UniProt Summary: Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chlorpromazine 10μM R07 exp344	-3.13
Nocodazole 0.2μM R00 exp24	-1.77
GSK-J4 1μM R07 exp362	1.7
NFN1 1μM R03 exp100	1.79
Alpha-Amanitin 0.5μM R00 exp5	1.84
Cytochalasin-B 5μM R07 exp349	1.91
Isonicotinamide 500μM R03 exp129	2.09
Betulinic acid 10 to 15μM on day4 R05 exp222	2.25
CCCP 0.1μM R00 exp10	2.38
Bisphenol S 100μM R08 exp458	2.7
Rapamycin 2μM plus FK-506 5μM R07 exp308	2.94

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

cyclosporin A binding
protein peptidyl-prolyl isomerization
peptidyl-prolyl cis-trans isomerase activity
peptidyl-proline modification
catalytic step 2 spliceosome
nuclear body
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
mRNA metabolic process
RNA processing
peptidyl-amino acid modification
RNA metabolic process
gene expression