RHEB

Entrez Summary: N/A
UniProt Summary: Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. {ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of type B pancreatic cell development
positive regulation of oligodendrocyte differentiation
positive regulation of TOR signaling
regulation of oligodendrocyte differentiation
positive regulation of glial cell differentiation
negative regulation of cold-induced thermogenesis
regulation of glial cell differentiation
positive regulation of gliogenesis
GDP binding
spliceosomal complex
regulation of TOR signaling
regulation of gliogenesis
regulation of epithelial cell differentiation
regulation of cold-induced thermogenesis
cell cycle arrest
regulation of macroautophagy
magnesium ion binding
postsynaptic density
lysosomal membrane
small GTPase mediated signal transduction
GTPase activity
regulation of autophagy
GTP binding
protein kinase binding
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
negative regulation of cell cycle
Golgi membrane
regulation of neurogenesis
regulation of cellular catabolic process
regulation of nervous system development
regulation of cell development
endoplasmic reticulum membrane
positive regulation of cell differentiation
regulation of catabolic process
cell cycle process
positive regulation of intracellular signal transduction
regulation of cell cycle
negative regulation of multicellular organismal process